A Randomised Clinical Trial of Physical Activity to Delay the Progression of Cerebrovascular Pathology

Grant number: 1005942 | Funding period: 2011 - 2015

Completed

Abstract

The aim of this randomised clinical trial is to establish whether a 24 months physical activity (PA) program for older adults with memory problems can delay the progression of damage to the blood vessel system in the brain, measured on an MRI scan. It also will investigate whether cognition, mood, quality of life, functional level, fitness and biological markers will improve with the intervention. If successful this PA program could become part of clinical care for adults at risk of dementia.

Related publications (5)

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Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

CE Sexton, KJ Anstey, F Baldacci, CJ Barnum, AM Barron, K Blennow, H Brodaty, S Burnham, FM Elahi, J Götz, YH Jeon, M Koronyo-Hamaoui, SM Landau, NT Lautenschlager, SM Laws, DM Lipnicki, H Lu, CL Masters, W Moyle, A Nakamura

2022-01-01

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting..

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A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer's Disease: The AIBL Active-Study

KL Cox, EV Cyarto, KA Ellis, D Ames, P Desmond, P Phal, MJ Sharman, C Szoeke, CC Rowe, CL Masters, E You, S Burrows, MMY Lai, NT Lautenschlager

2019-01-01

Background: Previous studies have demonstrated that physical activity (PA) interventions can improve physical and cognitive outcom..

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Physical activity and cognition in older adults with mild cognitive impairment and dementia

Nicola T Lautenschlager

2013-06-01

SUMMARYThere is increasing evidence that, next to multiple other health benefits, physical activity can also protect brain health ..

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Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial

EV Cyarto, NT Lautenschlager, PM Desmond, D Ames, C Szoeke, O Salvado, MJ Sharman, KA Ellis, PM Phal, CL Masters, CC Rowe, RN Martins, KL Cox

2012-10-11

Background: Older adults free of dementia but with subjective memory complaints (SMC) or mild cognitive impairment (MCI) are consi..

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The influence of exercise on brain aging and dementia

NT Lautenschlager, K Cox, EV Cyarto

2012-03-01

Physical activity has been recognized as an important protective factor reducing disability and mortality and therefore it is focu..